Protein Details: P2X receptor E

Protein ID

ICDB_Pro_0962

Protein Name

P2X receptor E

Gene Name

p2xE; DDB_G0288061

Organism

Dictyostelium discoideum (Social amoeba)

Length

388 amino acids

AlphaFoldDB

AF-Q54JH4-F1-model_v4.pdb

Function

P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Not essential for osmoregulation. Inward currents evoked by intracellular ATP. ATP analog beta; gamma-imido-ATP is a weak partial agonist of p2xE. Exclusively selective for ATP over other nucleotides. Insensitive to copper and P2 receptor antagonists PPADS and suramin but strongly inhibited by sodium ions. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. Permeable to calcium ions; but not chloride.

Sequence

MNFRNIDWDSLFSYSTIKIVRIRDKRLGILHFAFLIGIILYIIVGTIFLQKKYLVLESPIGSIRTSLMAPSVKPTDLPYCLKNGTDTSYDGYPNKPCQYWDEYLVLYPPSEESSMFITTRCTQETQSTVNGCNLSEPTCVYNTTSSSDFYIANVENFTILLDHTLSAPSLGIQYNGAQLNGQLLDTDGNPMSLPPPNIVGVKGSPDIMSLQGVLTAAGVESLDSQGLANKSRTIRDDGILILCFITYSNTYTYNTGNYHYTYQFKLVQNTKYKIVEPVFTKDVEDRYIFDRHGVRIIFIQTGQLGQFDFQTMLLTFVSGIGLVTAASLIVDIIATRIMPQRSRYQELKFQDSSINNTQKTPTNDHTPLLKDNEDTINENSYQNNSYEK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/nature03481; 10.1016/j.ceca.2008.04.001; 10.1074/jbc.m109.045674

RefSeq

XP_636957.2